Activity 1. Data integration, biobanking and Omics Technology
ACCC Tumor Documentation, Participation in Data Warehouse (Heidelberg, Dresden, Athens), Re-use local data management for ''ACCC Biobank'', Pave the way for participation in European initiatives (e.g. DKTK, Cancer Core Europe, BBMRI-ERIC).
Refers to all selected cancers. Head and neck, ovarian cancer, paediatric cancers initially.
Coordinators
Prof. S. Wiemann, Prof. Dr. F. Ückert (DKFZ) / Prof. E. Patsouris, Prof. A. Bamias, Dr. A. Chatziioannou (NHRF, Univ. Athens)
Data Integration
Key researchers-clinicians: A. Psyrri, A. Kattamis, M. Lablans, R. Knurr
Biobanking and Omics Technology
Key researchers-clinicians : A. Psyrri, A. Kattamis, M. Lablans, R. Knurr
Activity 2. Colorectal Cancer
Clinical level
Precision medicine translational approach, Genetic landscape of Hereditary Colorectal Cancer, heterogeneous Sporadic CRC clones, MSI related clinical trial, DNA repair, immunological profile.
Translational level
Establishment of 3D spheroid systems and patient derived xenografts (PDX). Patient oriented combination protocols, preclinical.
Coordinators
Prof. D. Jäger, Dr. N. Halama (DKFZ) / Dr. A. Pintzas, Prof. E. Patsouris (NHRF, Univ. Athens)
Key researchers-clinicians: Prof. D. Jäger, Dr. N. Halama (DKFZ), S. Wiemann, A. Dimitrakopoulou-Strauss, C. Ball, Dr. A. Pintzas, Dr. G. Zografos, D. Yannoukakos, A. Chatziioannou, V. Zoumpourlis, V. Souliotis, Prof. E. Patsouris (NHRF, Univ. Athens)
Activity 3. Multiple Myeloma
Standardization of the clinical data and biobanking, outcome of populations of special interest, asymptomatic myelomas, analysis of DNA damage response and repair.
Coordinators
Prof. Dr. H. Goldschmidt, Prof. Dr. A. Dimitrakopoulou-Strauss (DKFZ) / Prof. Dr. M.A. Dimopoulos, E. Terpos, E. Kastritis, V. Souliotis (NHRF, Univ. Athens)
Key researchers-clinicians: Coordinators, Dr. C. Sachpekidis
Activity 4. Pediatric Cancer
The main aim of this project is to involve the ACCC Pediatric Oncology Department in ongoing molecular matching studies in pediatric (neuro-)oncology to allow for participation in stratified European trials (e.g., PNET5 or trials using molecular targeted drugs).
Coordinators
Prof. Dr. S. Pfister (DKFZ) / Prof. Dr. A. Kattamis (NHRF, Univ. Athens)
Activity 5. Small animal imaging
Small animal cancer imaging, development of optical imaging probes by coupling nanoparticles with appropriate biomolecules (peptides, monoclonal antibodies) and fluorescent dyes or conjugated polymers, for targeted imaging of diseased sites.
Coordinators
Prof. Dr. A. Dimitrakopoulou-Strauss (DKFZ) / Dr. V. Gregoriou, Dr. A. Pintzas (NHRF)
Key researchers-clinicians: Coordinators, C. Chochos, P. Bouzioti, A. Provata
